EDINBURGH DERMATOPATHOLOGY

 

 

 

 

 

 

 

 

 

THOMAS BRENN MD PHD FRCPath

(bio sketch)

 

 

 

 

 

 

 

 

                     

 

 

 

 

  Dr. Thomas Brenn graduated magna cum laude from the Ruprecht-Karls University of Heidelberg (Heidelberg, Germany) where he received his MD and PhD degrees. After postdoctoral fellowships in the Departments of Genetics and Pathology at Stanford University (Stanford, CA, USA) and residency training in Anatomic Pathology at the Brigham and Women’s Hospital (Boston, MA, USA), he pursued subspecialty fellowships with Drs Phillip McKee and Christopher Fletcher in Dermatopathology, Soft Tissue Tumor Pathology and Surgical Pathology. In 2003, Dr. Brenn joined the faculty of the Brigham and Women’s Hospital and Harvard Medical School and was a consultant in pathology at Dana Farber Cancer Institute.  In 2007, he was made Consultant Dermatopathologist and Head of Dermatopathology at NHS Lothian University Hospitals Trust and Honorary Senior Lecturer at the University of Edinburgh (Edinburgh, Scotland). Dr. Brenn is a Diplomate of the American Board of Pathology (Anatomic Pathology) and Dermatology (Dermatopathology). He is the current Chair of the Skin Working Group of the European Society of Patology (ESP) and Chief Examiner for the RCPath Diploma in Dermatopathology. He is also a member of the steering committee of the National Specialist EQA scheme in Dermatopathology and was an executive committee member of the British Society for Dermatopathology.  He has contributed to major textbooks in Dermatology as well as Dermtopathology and is a co-editor of the 4th edition of McKee’s Pathology of the Skin. His busy referral practice reflects his clinical and research interests related predominantly to the pathology of cutaneous soft tissue tumours, skin adnexal tumours as well as melanocytic tumour pathology.  Dr. Brenn is actively involved in clinical as well as translational research and particularly enjoys teaching dermatopathology to a wide range of audiences at national and international meetings.

 

 

Edited Books

 

McKee’s Pathology of the Skin, 4th edition, by Calonje JE, Brenn T, Lazar A and McKee PH (eds.) 2012. Elsevier.

 

Authored Book Chapters

 

1. Brenn T and McKee PH.

           Chapter 22: Tumors of surface epithelium.

           Chapter 27: Tumors of the hair follicle.

           Chapter 29: Tumors of the sweat glands.

 

      In: “Pathology of the Skin”, McKee PH, Calonje JE, Granter S (eds.). 2005. Elsevier.

2. Brenn T, McKee PH and Mihm MC. Chapter 26: Vascular neoplasms.

 

      In: “Cancer of the skin”, Rigel DS, Friedman R, Dzubow LM, Reintgen DS, Bystryn J-C, and Marks R (eds.). 2005. W.B. Saunders.

3. Brenn T. Cutaneous Myoepithlioma AND Microcystic Adnexal Carcinoma. 

     

     In: “Cases in Dermatopathology. Adnexal Neoplasms”, Zembowicz A, Flotte T, Mihm MC, Murphy GF, Tahan S (eds.), chapters 14 and 15. 2005. KBS Publishing.

4. Brenn T. Cutaneous Myoepithlioma.

 

     In: “Cases in Dermatopathology. Common Problems in Diagnosis of Pigmented Lesions”, Zembowicz A, Flotte T, Mihm MC, Murphy GF, Tahan S (eds.), chapter 29. 2006. KBS Publishing.

5. Brenn T. Chapter 129: Neoplasms of Subcutaneous Fat.

 

      In: “Fitzpatrick’s Dermatology in General Medicine, 7th ed”, Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller A, Leffell DJ (eds.). 2007. McGraw-Hill.

6. Brenn T.  Superficial Soft Tissue Lesions AND Psoriasiform and Lichenoid Dermatoses

 

      In: Dermatopathology Update Series",McKee PH, Goodlad J, Brenn T, Hollowood K (eds.). 2008.Medilink Publications, Manchester.

 

7. Brenn T. Chapter 129: Neoplasms of Subcutaneous Fat.

 

      In: “Fitzpatrick’s Dermatology in General Medicine, 8th ed”, Goldsmith LA, Katz SI, Gilchrest BA, Paller A, Leffell DJ, Wolff K (eds.). 2012. McGraw-Hill.

8. Brenn T and Hornick JL. Chapter 15: Cutaneous Mesenchymal Tumours.

 

      In: “Practical Soft Tissue Pathology”, Hornick JL (ed.). 2012. Elsevier.

 

9. Brenn T. 

Blue nevus                 

Lentigo simplex

Lentigo, solar (senile)

Nevus, common acquired

Nevus, congenital

Nevus, of Ito

Nevus, of Ota

Nevus, Reed

Spitz nevus

In: “Encyclopedia of Pathology”, van Krieken JHJM (ed.). 2013. Springer, in press.

 

10. Brenn T  and Calonje E.Chapter 5: Melanocytic Lesions of the Vulva and Vagina.

      In: “Pathology of the Vulva and Vagina, Essentials of Diagnostic Gynecological Pathology", Brown L (ed.). 2013.   Springer-Verlag, London.

 

11. Brenn T  and Calonje E.Chapter 5: Melanocytic Lesions of the Vulva and Vagina.

       In: “Pathology of the Vulva and Vagina, Essentials of Diagnostic Gynecological Pathology", Brown L (ed.). 2013.Springer-Verlag, London.

12. Calonje E and Brenn T. Chpater 33: Vascuar Tumors.

       In: “Lever’s Histopathology of the Skin, 11th edition”, Elder DE (ed.). in print, Wolters and Kluwer Health.

13. Calonje JE, Komminoth P and Brenn T. Chapter 12-7: Atypical Fibroxanthoma.

      In: “World Health Organization Classification of Tumours, 4th edition: Pathology and Genetics of Tumours of Soft Tissue and Bone",

      Fletcher CDM, Hogendoors PCW, Bridge JA, Mertens F (eds.). 2013.IARC, Lyon.

 

Original Peer-reviewed Articles

   

  1. Wood A, Mentzel T, van Gorp J, Flucke U, Huschka U, Schneider J, Bacchi, CE, Calonje E, Brenn T. The spectrum of rare morphological variants of cutaneous epithelioid angiosarcoma. 2014, in print.
  2. Hauser B, McRorie E, McKay N, Brenn T, Amft N. A case of hypocomplementaemic urticarial vasculitis with cardiac valve involvement successfully treated with cyclophosphamide and high-dose glucocorticoids. Int J Rheum Dis. 2014 Apr 5.
  3. Griewank KG, Schilling B, Murali R, Bielefeld N, Schwamborn M, Sucker A, Zimmer L, Hillen U, Schaller J, Brenn T, Schadendorf D, Mentzel T. TERT promoter  mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas. Mod Pathol. 2014;27(4): 502-8.
  4. Thum C, Husain EA, Mulholland K, Hornick JL, Brenn T. Atypical fibroxanthoma with pseudoangiomatous features: a histological and immunohistochemical mimic of cutaneous angiosarcoma. Ann Diagn Pathol. 2013; 17(6): 502-7.
  5. Ramakrishnan R, Chaudhry IH, Ramdial P, Lazar AJ, McMenamin ME, Kazakov D, Brenn T, Calonje E. Primary Cutaneous Adenoid Cystic Carcinoma: A Clinicopathologic and Immunohistochemical Study of 27 Cases. Am J Surg Pathol. 2013; 37(10): 1603-1611.
  6. Martin B, Poblet E, Rios JJ, Kazakov D, Kutzner H, Brenn T, Calonje E. Merkel Cell Carcinoma with Divergent Differentiation: Histopathological and immunohistochemical study of 15 cases with PCR analysis for Merkel Cell Polyomavirus. Histopathology 2013, 62(4): 711-722.
  7. Ferrara G, Misciali C, Brenn T, Cerroni L, Kazakov DW, Perasole A, Russo R, Ricci R, Crisman G, Fanti PA, Passarini B, Patrizi A. The Impact of MolecularMorphology Techniques on the Expert Diagnosis in Melanocytic Skin Neoplasms. Int  J Surg Pathol. 2013; 21(5): 483-92.Song L, Li W, Doig T, Brenn T, Mathers M, Nrown ERS, Doherty V, Bartlett JMS, Anderson N, and Melton DW. DNA repair proteins as prognostic and predictive markers in melanoma. Histopathology. 2013, 62(2): 343-350.
  8. Suchak R, Wang WL, PrietoVG, Ivan D, Lazar AJ, Brenn T, Calonje E. Cutaneous Digital Papillary Adenocarcinoma: a clinicopathologic study of 31 cases of a rare neoplasm with new observations. Am J Surg Pathol 2012, 36(12):1883-91.
  9. Miller K, Goodlad JR, Brenn T. Pleomorphic dermal sarcoma: adverse histologic features predict aggressive behavior and allow distinction from atypical fibroxanthoma. Am J Surg Pathol. 2012; 36(9): 1317-26.
  10. Miller K, Hall RC, Brenn T. Spitz nevus withHomer-Wright rosette-like structures. Am J Dermatopathol. 2012; 34(4): 457-9.
  11. Song L, Li W, Doig T, Brenn T, Mathers M, Nrown ERS, Doherty V, Bartlett JMS, Anderson N, and Melton DW. DNA repair proteins as prognostic and predictive markers in melanoma. Histopathology. 2013, 62(2): 343-350.
  12. Xu Y, Brenn T, Brown ER, Doherty V, Melton DW. Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors. Br J Cancer. 2012;31; 106(3): 553-61.
  13. Brown ER, Doig T, Anderson N, Brenn T, Doherty V, Xu Y, Bartlett JM, Smyth JF, Melton DW. Association of galectin-3 expression with melanoma progression and prognosis. Eur J Cancer. 2012; 48(6): 865-74.
  14. Thum C, Hollowood K, Birch J, Goodlad JR, Brenn T. Aberrant Melan-A expression in atypical fibroxanthoma and undifferentiated pleomorphic sarcoma of the skin. J Cutan Pathol. 2011; 38(12): 954-60.
  15. Trufant JW, Brenn T, Fletcher CD, Virata AR, Cook DL, Bosenberg MW. Melanotic Schwannoma Arising in Association With Nevus of Ota: 2 Cases Suggesting a Shared Mechanism. Am J Dermatopathol. 2009, 31(8): 808-13.
  16. Rutter KJ, Watson RE, Cotterell LF, Brenn T, Griffiths CE, Rhodes LE. SeverelyPhotosensitive Psoriasis: A Phenotypically Defined Patient Subset. J InvestDermatol. 2009, 129(12): 2861-7.
  17. Friedberg JW, Kelly JL, Neuberg D, Peterson DR, Kutok JL, Salloum R, Brenn T, Fisher DC, Ronan E, Dalton V, Rich L, Marquis D, Sims P, Rothberg PG, Liesveld J,Fisher RI, Coffman R, Mosmann T, Freedman AS. Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma. Br J Haematol. 2009, 146(3): 282-91.
  18. Wang WL, Hornick JL, Mallipeddi R, Zelger BG, Rother JD, Yang D, Lev DC, Trent JC, Prieto VG, Brenn T, Calonje E, Lazar AJ. Cutaneous and subcutaneous metastases of gastrointestinal stromal tumors: a series of 5 cases with molecular analysis. Am J Dermatopathol. 2009 May;31(3): 297-300.
  19. Haining WN, Davies J, Kanzler H, Drury L, Brenn T, Evans J, Angelosanto J, Rivoli S, Russell K, George S, Sims P, Neuberg D, Li X, Kutok J, Morgan J, Wen P,Demetri G, Coffman RL, Nadler LM. CpG oligodeoxynucleotides alter lymphocyte and dendritic cell trafficking in humans. Clin Cancer Res. 2008, 14(17): 5626-34.
  20. Hollmann TJ, Brenn T, Hornick JL. CD25 expression on cutaneous mast cells from adult patients presenting with urticaria pigmentosa is predictive of systemic mastocytosis. Am J Surg Pathol 2008, 32(1): 139-145.
  21. Gleason BC, Hirsch MS, Nucci MR, Schmidt BA, Zemboxicz A, Mihm MC, McKee PH, Brenn T. Atypical genital nevi: a clinicopathologic analysis of 56 cases. Am J Surg Pathol 2008, 32(1): 51-57.
  22. Tolland JP, Brenn T, Guldbakke KK, Schanbacher CF. Mohs micrographic surgery, sentinel lymph node mapping, and estrogen receptor analysis for the treatment of malignant nodular hidradenoma. Dermatol Surg 2006,32(10):1294-301.
  23. Natarajan E, Omobono JD 2nd, Guo Z, Hopkinson S, Lazar AJ, Brenn T, Jones JC, Rheinwald JG. A keratinocyte hypermotility/growth-arrest response involving laminin 5 andp16INK4A activated in wound healing and senescence.Am J Pathol 2006, 168(6): 1821-37.
  24. Brenn T and Fletcher CD. Radiation-induced cutaneous atypical vascular lesions and angiosarcoma: Clinicopathologic analysis of 42 cases. Am J Surg Pathol 2005, 29(8): 983-996.
  25. Brenn T and Fletcher CD. Cutaneous epithelioid angiomatous nodule: a distinct lesion in the morphologic spectrum of epithelioid vascular tumors. Am J Dermatopathol 2004, 26(1): 14-21.
  26. Brenn T, Calonje E, Granter SR, Leonard N, Grayson W, Fletcher CD, McKee PH. Cutaneous Rosai-Dorfman disease is a distinct clinical entity. Am J Dermatopathol 2002, 24(5): 385-91.
  27. Schrijver I, Liu W, Odom R, Brenn T, Oefner P, Furthmayr H, Francke U. Premature termination mutations in FBN1: distinct effects on differential allelic expression and on protein and clinical phenotypes. Am J Hum Genet 2002, 71(2): 223-37.
  28. Liu W, Schrijver I, Brenn T, Furthmayr H, Francke U.Multi-exon deletions of the FBN1 gene in Marfan syndrome. BMC Med Genet 2001, 2(1): 11.
  29. Schrijver I, Liu W, Brenn T, Furthmayr H, Francke U.Cysteine substitutions in epidermal growth factor-like domains of fibrillin-1: Distinct effects on biochemical and clinical phenotypes. Am J Hum Genet 1999, 65(4): 1007-1020.
  30. Brenn T, Aoyama T, Francke U, Furthmayr H.Dermal fibroblast culture as a model system for studies of fibrillin assembly and pathogenetic mechanisms: defects in distinct groups of individuals with Marfan's syndrome. Lab Invest 1996, 75(3): 389-402.
  31. Liu W, Qian C, Comeau K, Brenn T, Furthmayr H, Francke U.Mutant fibrillin-1 monomers lacking EGF-like domains disrupt microfibril assembly and cause severe Marfan syndrome. Hum Mol Genet 1996, 5(10): 1581-7.
  32. Schmidt MC, Klues HG, vom Dahl J, Brenn T, Hugel W, Hanrath P.Intracoronary Doppler flow velocity measurements in two patients with solitary coronary ostium: is there true obstruction? Coron Artery Dis 1996, 7(10): 761-5.
  33. Francke U, Berg MA, Tynan K, Brenn T, Liu W, Aoyama T, Gasner C, Miller DC, Furthmayr H.A Gly1127Ser mutation in an EGF-like domain of the fibrillin-1 gene is a risk factor for ascending aortic aneurysm and dissection. Am J Hum Genet 1995, 56(6): 1287-96.
  34. Eldadah ZA, Brenn T, Furthmayr H, Dietz HC. Expression of a mutant human fibrillin allele upon a normal human or murine genetic background recapitulates a Marfan cellular phenotype. J Clin Invest 1995, 95(2): 874-80.
  35. Richardt G, Brenn T, Seyfarth M, Haass M, Schömig E, Schömig A. Dual effect of nicotine on cardiac noradrenaline release during metabolic blockade. Basic Res Cardiol 1994, 89(6): 524-34.
  36. Haass M, Richardt G, Brenn T, Schömig E, Schömig A. Nicotine-induced release of noradrenaline and neuropeptide Y in guinea-pig heart: role of calcium channels and protein kinase C. Naunyn-Schmiedebergs Arch Pharmacol 1991, 344(5): 527-31.

Invited Review Articles

 

1.    Brenn T. Pleomorphic Dermal Neoplasms: A Review. 2014Adv Anat Pathol, 21(2): 108-30.

2.    Brenn T. Pitfalls in the evaluation of melanocytic lesions. Histopathology. 2012; 60: 690-705.

3.    Brenn T. Atypical Genital Nevus. Arch Pathol Lab Med.2011; 135(3): 317-20.

4.    Brenn T and McKee PHM. Melanoma in children and adolescents. Diagnostic Histopathology. 2008; 14: 18-27.

5.    Brenn T and Fletcher CDM. Post-radiation vascular proliferations: an increasing problem. Histopathology. 2006 48: 106-114.

6.    Richardt G, Haass M, Brenn T, Schömig E, Schömig A. 1991 Nicotine-induced release of noradrenaline and neuropeptide Y in the heart: dependence on calcium, potassium and pH. In “Effect of nicotine on biological systems”, Adlkofer F, Thurau K (eds.), pp 197-203. Birkhäuser Verlag, Basel